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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SGEF All Species: 8.79
Human Site: S419 Identified Species: 21.48
UniProt: Q96DR7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DR7 NP_056410.3 871 97360 S419 K P L R S T W S Q L S A V K R
Chimpanzee Pan troglodytes XP_001146545 871 97327 S419 K P L R S T W S Q L S A V K R
Rhesus Macaque Macaca mulatta XP_001082733 709 80324 G273 L P E V V E L G I L D Q L S T
Dog Lupus familis XP_854672 589 67618 Q153 G L S Q T V S Q E E R K R Q E
Cat Felis silvestris
Mouse Mus musculus Q3U5C8 713 80377 G277 L P E V L E S G V L D T L S T
Rat Rattus norvegicus Q5BKC9 701 80989 L265 L Q P E E T K L Q E A M F E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511351 1102 121173 S651 K P L R S T W S Q L S V V K R
Chicken Gallus gallus XP_426718 770 85723 Q334 G L S E T I S Q E E R K R Q E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001116755 606 69197 E170 D E P R F Y Q E I K E R G L N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_494706 1136 128641 C638 G S Q R S L W C E L P E V R A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.1 37.3 65.5 N.A. 37 28.4 N.A. 52.8 67.7 N.A. 33.1 N.A. N.A. N.A. 27.1 N.A.
Protein Similarity: 100 98.5 52.9 66.2 N.A. 51.7 45.2 N.A. 62 74.4 N.A. 47.7 N.A. N.A. N.A. 44.8 N.A.
P-Site Identity: 100 100 13.3 0 N.A. 13.3 13.3 N.A. 93.3 0 N.A. 6.6 N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: 100 100 20 26.6 N.A. 20 26.6 N.A. 93.3 20 N.A. 6.6 N.A. N.A. N.A. 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 10 20 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % D
% Glu: 0 10 20 20 10 20 0 10 30 30 10 10 0 10 20 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 30 0 0 0 0 0 0 20 0 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 20 0 0 0 0 0 0 % I
% Lys: 30 0 0 0 0 0 10 0 0 10 0 20 0 30 0 % K
% Leu: 30 20 30 0 10 10 10 10 0 60 0 0 20 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 50 20 0 0 0 0 0 0 0 10 0 0 0 0 % P
% Gln: 0 10 10 10 0 0 10 20 40 0 0 10 0 20 0 % Q
% Arg: 0 0 0 50 0 0 0 0 0 0 20 10 20 10 30 % R
% Ser: 0 10 20 0 40 0 30 30 0 0 30 0 0 20 0 % S
% Thr: 0 0 0 0 20 40 0 0 0 0 0 10 0 0 20 % T
% Val: 0 0 0 20 10 10 0 0 10 0 0 10 40 0 0 % V
% Trp: 0 0 0 0 0 0 40 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _